DNA Triplexes-Guided Assembly of G-Quadruplexes for Constructing Label-free Fluorescent Logic Gates

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• 作者：Lijun Xu ; Shanni Hong ; Xiaoqiang Shen ; Lu Zhou ; Jine Wang ; Jianye Zhang and Prof. Dr. Renjun Pei
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：July 5, 2016
• 年：2016
• 卷：11
• 期：13
• 页码：1892-1895
• 全文大小：724K
• ISSN：1861-471X

文摘

Assembly of G-quadruplexes guided by DNA triplexes in a controlled manner is achieved for the first time. The folding of triplex sequences in acidic conditions brings two separated guanine-rich sequences together and subsequently a G-quadruplex structure is formed in the presence of K⁺. Based on this novel platform, label-free fluorescent logic gates, such as AND, INHIBIT, and NOR, are constructed with ions as input and the fluorescence of a G-quadruplex-specific fluorescent probe NMM as output.