Metal-Organic-Framework-Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small-Molecule-Polymer Conjugates

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• 作者：Shuo Liu ; Jianbin Chen ; Xiaojia Bao ; Tao Li ; Yunyang Ling ; Chunxiang Li ; Prof. Dr. Chuanliu Wu and Prof. Dr. Yibing Zhao
• 刊名：Chemistry – An Asian Journal
• 出版年：2016
• 出版时间：June 21, 2016
• 年：2016
• 卷：11
• 期：12
• 页码：1811-1820
• 全文大小：1700K
• ISSN：1861-471X

文摘

Herein, we report a strategy for exploiting nanoscale metal–organic frameworks (nano-MOFs) as templates for the layer-by-layer (LbL) assembly of polyelectrolytes. Because small-molecule drugs or imaging agents cannot be efficiently encapsulated by polyelectrolyte nanocapsules, we investigated two promising and biocompatible polymers (comb-shaped polyethylene glycol (PEG) and hyperbranched polyglycerol-based PEG) for the conjugation of model drugs and imaging agents, which were then encapsulated inside the nano-MOF-templated nanocapsules. Furthermore, we also systemically explored the release kinetics of the encapsulated conjugates, and examined how the encapsulation and/or release processes could be controlled by varying the composition and architecture of the polymers. We envision that our nano-MOFs-templated nanocapsules, through combining with small-molecule–polymer conjugates, will represent a new type of delivery system that could open up new opportunities for biomedical applications.