Copper-Catalyzed C−N Bond Formation via Oxidative Cross-Coupling of Amines with -Aminocarbonyl Compounds

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• 作者：Xing-Xing Liu ; Zhao-Yang Wu ; Yong-Qin He ; Xiao-Qiang Zhou ; Ting Hu ; Chao-Wei Ma and Guo-Sheng Huang
• 刊名：Advanced Synthesis & Catalysis
• 出版年：2016
• 出版时间：July 28, 2016
• 年：2016
• 卷：358
• 期：15
• 页码：2385-2391
• 全文大小：904K
• ISSN：1615-4169

文摘

A novel and selective method for the simple copper-catalyzed α-amination of α-aminocarbonyl compounds to afford 2-amino-2-iminocarbonyl and 2-amino-2-oxocarbonyl compounds is reported. This transformation is achieved by C(sp³)−H and N−H bond oxidative cross-coupling and selective C−N bond oxidative cleavage. This reaction system has a broad reaction scope, providing a facile pathway for the α-functionalization of α-amino ketones.