Copper-Catalyzed Redox-Triggered Remote CH Functionalization: Highly Selective Formation of CCF3 and CO Bonds

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• 作者：Taotao Li ; Peng Yu ; Jin-Shun Lin ; Yonggang Zhi and Xin-Yuan Liu
• 刊名：Chinese Journal of Chemistry
• 出版年：2016
• 出版时间：May, 2016
• 年：2016
• 卷：34
• 期：5
• 页码：490-494
• 全文大小：397K
• ISSN：1614-7065

文摘

A Cu-catalyzed remote sp³ CH/unactivated alkenes functionalization reaction for the concomitant construction of CCF₃ and CO bonds was described. An 1,5-H radical transfer involving an sp³ CH bond adjacent to a nitrogen atom and an α-CF₃-alkyl radical intermediate derived from unactivated alkenes was observed and demonstrated to proceed via the radical process.