One-Pot Aqueous Synthesis of Highly Biocompatible Near Infrared CuInS2 Quantum Dots for Target Cell Imaging

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• 作者：Anila Arshad ; Hongli Chen ; Xilin Bai ; Suying Xu and Leyu Wang
• 刊名：Chinese Journal of Chemistry
• 出版年：2016
• 出版时间：June, 2016
• 年：2016
• 卷：34
• 期：6
• 页码：576-582
• 全文大小：2100K
• ISSN：1614-7065

文摘

In this study, we report a novel and facile autoclave strategy for synthesis of near-infrared (NIR) CuInS₂ QDs by employing glutathione (GSH) as capping ligand and stabilizer in aqueous media under 100°C. Various experimental parameters including the ratio of precursors, reaction time, reaction temperature, pH effect and stability have been systematically studied. The QDs were characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), and Fourier transform infrared spectroscopy (FT-IR). The as-synthesized NIR QDs exhibited low cytotoxicity and maintained excellent cell viability even up to 100 µg/mL. After bioconjugation with Arg-Gly-Asp (RGD) peptide, the obtained CuInS₂-RGD QDs have demonstrated high targeting ability with good fluorescence cell imaging performance.