Facile Synthesis of Yolk-Shell-Structured Triple-Hybridized Periodic Mesoporous Organosilica Nanoparticles for Biomedicine

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• 作者：Zhaogang Teng ; Junjie Zhang ; Wei Li ; Yuanyi Zheng ; Xiaodan Su ; Yuxia Tang ; Meng Dang ; Ying Tian ; Lihui Yuwen ; Lixing Weng ; Guangming Lu and Lianhui Wang
• 刊名：Small
• 出版年：2016
• 出版时间：July 13, 2016
• 年：2016
• 卷：12
• 期：26
• 页码：3550-3558
• 全文大小：4976K
• ISSN：1613-6829

文摘

The synthesis of mesoporous nanoparticles with controllable structure and organic groups is important for their applications. In this work, yolk–shell-structured periodic mesoporous organosilica (PMO) nanoparticles simultaneously incorporated with ethane-, thioether-, and benzene-bridged moieties are successfully synthesized. The preparation of the triple-hybridized PMOs is via a cetyltrimethylammonium bromide-directed sol–gel process using mixed bridged silsesquioxanes as precursors and a following hydrothermal treatment. The yolk–shell-structured triple-hybridized PMO nanoparticles have large surface area (320 m² g^–1), ordered mesochannels (2.5 nm), large pore volume (0.59 cm³ g^–1), uniform and controllable diameter (88–380 nm), core size (22–110 nm), and shell thickness (13–45 nm). In vitro cytotoxicity, hemolysis assay, and histological studies demonstrate that the yolk–shell-structured triple-hybridized PMO nanoparticles have excellent biocompatibility. Moreover, the organic groups in the triple-hybridized PMOs endow them with an ability for covalent connection of near-infrared fluorescence dyes, a high hydrophobic drug loading capacity, and a glutathione-responsive drug release property, which make them promising candidates for applications in bioimaging and drug delivery.