siRNA Delivery: Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing (Small 27/2016)

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• 作者：Chao Chen ; Paola Posocco ; Xiaoxuan Liu ; Qiang Cheng ; Erik Laurini ; Jiehua Zhou ; Cheng Liu ; Yang Wang ; Jingjie Tang ; Valentina Dal Col ; Tianzhu Yu ; Suzanne Giorgio ; Maurizio Fermeglia ; Fanqi Qu ; Zicai Liang ; John J. Rossi ; Minghua Liu ; Palma Rocchi ; Sabrina Pricl and Ling Peng
• 刊名：Small
• 出版年：2016
• 出版时间：July 20, 2016
• 年：2016
• 卷：12
• 期：27
• 页码：3604
• 全文大小：3404K
• ISSN：1613-6829

文摘

Supramolecular dendrimers created from small amphiphilic dendrons are able to mimic covalently constructed high-generation dendrimers for siRNA delivery, as presented by S. Pricl, L. Peng, and co-workers on page 3667. An optimal balance between the hydrophobic alkyl chain length and the hydrophilic dendritic portion is crucial for self-assembly of these amphiphilic dendrons into micellar nanostructures, and critically impacts the effectiveness of siRNA delivery and functional gene silencing.