Multiple human papillomavirus infections and type-competition in women from a clinic attendee population in China

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• 作者：Jianhui Nie ; Jianhua Liu ; Hui Xie ; Zhengrong Sun ; Juan Zhao ; Qingqing Chen ; Yangyang Liu ; Weijin Huang ; Qiang Ruan and Youchun Wang
• 刊名：Journal of Medical Virology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：88
• 期：11
• 页码：1989-1998
• 全文大小：1536K
• ISSN：1096-9071

文摘

To investigate the multi-infection patterns and type competition for human papillomavirus (HPV) in Chinese clinic attending women and evaluate the association between the infection status and cancer risk. Three hundred and thirty-two HPV-DNA-positive samples were genotyped for 21 HPVs and tested for 13 types of HPV neutralizing antibody using pseudoviron-based assay. Odds ratios (ORs) were calculated to evaluate the coinfection patterns for both DNA and neutralizing antibody (NAb), and the associations of HSIL+ with HPV DNA and NAb. Of the 332 HPV-DNA-positive subjects, 279 (84.0%) were detected as NAb positive. Multi-positive results were identified in 23.2% (77/332) HPV DNA tests and 60.2% (168/279) HPV NAb assays. The NAb titers for the multiple-positive samples (geometric mean 214) were significantly higher than the single-positive samples (geometric mean 114) (P < 0.01). HPV16-HPV52 was identified as a type-competition pair for both HPV DNA (OR = 0.09; 95%CI = 0.02–0.42) and NAb (OR = 0.27; 95%CI = 0.11–0.69) data. Compared to other types, HPV16 DNA was associated significantly with high risk of HSIL+ (OR = 2.57; 95%CI = 1.23–5.38). HPV16-HPV52 was identified as a potential type-competition pair, which might result in the type modulation with the implementation of the approved bi- or quadri-valent vaccines. J. Med. Virol. 88:1989–1998, 2016.