Chaephilones A and B, Two New Azaphilone Derivatives Isolated from Chaetomium globosum

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• 作者：Chunmei Chen ; Jing Wang ; Hucheng Zhu ; Jianping Wang ; Yongbo Xue ; Guangzheng Wei ; Yi Guo ; Dongdong Tan ; Jinwen Zhang ; Chunping Yin and Yonghui Zhang
• 关键词：Chaetomium globosum ; Azaphilone derivatives ; Chaephilones A and B
• 刊名：Chemistry & Biodiversity
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：13
• 期：4
• 页码：422-426
• 全文大小：213K
• ISSN：1612-1880

文摘

Two new azaphilone derivatives, chaephilones A (1) and B (2), were isolated from the fungus Chaetomium globosum, together with four structurally related analogs 3 – 6. The structures of 1 and 2 were elucidated by comprehensive spectroscopic analyses including HR-ESI-MS and NMR. The known compounds were identified as chaetomugilin Q (3), chaetomugilin D (4), 11-epichaetomugilin A (5), and chaetomugilin S (6) by comparing their NMR data and optical rotation values with those reported. Compound 2 represents the first example of azaphilone with an open furan ring. Compounds 1 and 2 were evaluated for cytotoxic activities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480) by the MTS method.