Biomimetic Nanofluidic Diode Composed of Dual Amphoteric Channels Maintains Rectification Direction over a Wide pH Range

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• 作者：Dr. Xin Sui ; Dr. Zhen Zhang ; Dr. Zhenyu Zhang ; Zhiwei Wang ; Chao Li ; Dr. Hao Yuan ; Prof. Dr. Longcheng Gao ; Prof. Dr. Liping Wen ; Prof. Dr. Xia Fan ; Prof. Dr. Lijun Yang ; Prof. Dr. Xinru Zhang and Prof. Dr. Lei Jiang
• 刊名：Angewandte Chemie
• 出版年：2016
• 出版时间：October 10, 2016
• 年：2016
• 卷：128
• 期：42
• 页码：13250-13254
• 全文大小：1309K
• ISSN：1521-3757

文摘

pH-gated ion channels in cell membranes play important roles in the cell's physiological activities. Many artificial nanochannels have been fabricated to mimic the natural phenomenon of pH-gated ion transport. However, these nanochannels show pH sensitivity only within certain pH ranges. Wide-range pH sensitivity has not yet been achieved. Herein, for the first time, we provide a versatile strategy to increase the pH-sensitive range by using dual amphoteric nanochannels. In particular, amphoteric polymeric nanochannels with carboxyl groups derived from a block copolymer (BCP) precursor and nanochannels with hydroxyl groups made from anodic alumina oxide (AAO) were used. Due to a synergistic effect, the hybrid nanochannels exhibit nanofluidic diode properties with single rectification direction over a wide pH range. The novel strategy presented here is a scalable, low-cost, and robust alternative for the construction of large-area membranes for nanofluidic applications, such as the separation of biomolecules.