Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway

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• 作者：Qi-an Han ; Chunhong Yan ; Lingfang Wang ; Guanghui Li ; Yunfeng Xu and Xiaodong Xia
• 刊名：Molecular Nutrition & Food Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：60
• 期：9
• 页码：1933-1943
• 全文大小：965K
• ISSN：1613-4133

文摘

Endothelial dysfunction and inflammation are both common events occurring during the development of atherosclerosis. Previous studies have shown that urolithins, the intestinal microflora metabolites of ellagitannin, exhibit anti-inflammation and antioxidative properties. This study aims to investigate the protective effect of urolithin A (UA) on ox-LDL-induced (where ox-LDL is oxidized low-density lipoprotein) endothelial dysfunction and possible modes of action.