Myrothecoside, a Novel Glycosylated Polyketide from the Terrestrial Fungus Myrothecium sp. GS-17

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• 作者：Songya Zhang ; Jing Zhu ; Tao Liu ; Suzan Samra ; Huaqi Pan ; Jiao Bai ; Huiming Hua and Andreas Bechthold
• 关键词：Secondary metabolites ; Fungi ; Myrothecium ; Glycosylated polyketides ; Antibacterial activity
• 刊名：Helvetica Chimica Acta
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：99
• 期：3
• 页码：215-219
• 全文大小：170K
• ISSN：1522-2675

文摘

Based on the chemical analysis and targeted bioactivity screening, a new polyketide glycoside, myrothecoside, was isolated from a terrestrial halotolerant fungus, Myrothecium sp. GS-17. The structure of myrothecoside was elucidated on the basis of extensive spectroscopic analysis including 1D- and 2D-NMR (¹H,¹H-COSY, HSQC, HMBC, and NOESY) experiments, combined with mass spectroscopic data and physicochemical properties. This compound exhibited weak cytotoxicity against human leukemia (HL-60) cancer cell with an IG₅₀ value of 63.61 μm, and also antifungal activities against plant pathogenic fungi Rhizoctonia solani and Fusarium oxysporum using standard agar diffusion tests at 20 μg/disk.