Two New Flavonoids from Derris eriocarpa How

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• 作者：Hua-Yong Lou ; Hong-Guo Wu ; Yong-Hua Tan ; Jun-Jie Lan ; Xiao-Pan Ma ; Guang-Yi Liang ; Ping Yi and Wei-Dong Pan
• 关键词：Derris eriocarpa ; Flavonoids ; Anticancer activity
• 刊名：Helvetica Chimica Acta
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：99
• 期：4
• 页码：302-305
• 全文大小：387K
• ISSN：1522-2675

文摘

Two new flavonoids, 1 and 2, together with two known flavonoids, tephrosin (3) and 12a-hydroxy--toxicarol (4), were isolated from the whole herb of Derris eriocarpa How. The structures and absolute configurations of the new compounds were elucidated on the basis of their MS, NMR, and ECD data. The structures of the known compounds were established by extensive spectroscopic (MS, 1D- and 2D-NMR) analyses and comparison with the literature data. All compounds were isolated from D. eriocarpa for the first time. Compound 3 showed modest inhibitory activities against the growth of human cancer cells HEL and A549 with the IC₅₀ values of 15.03 ± 0.62 and 13.27 ± 0.39 μm, respectively.