Neuroinflammatory component of gray matter pathology in multiple sclerosis

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• 作者：Elena Herranz ; Costanza Giann&igrave ; Cé ; line Louapre ; Constantina A. Treaba ; Sindhuja T. Govindarajan ; Russell Ouellette ; Marco L. Loggia ; Jacob A. Sloane ; Nancy Madigan ; David Izquierdo-Garcia ; Noreen Ward ; Gabriel Mangeat ; Tobias Granberg ; Eric C. Klawiter ; Ciprian Catana ; Jacob M. Hooker ; Norman Taylor ; Carolina Ionete ; Revere P. Kinkel and Caterina Mainero
• 刊名：Annals of Neurology
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：80
• 期：5
• 页码：776-790
• 全文大小：720K
• ISSN：1531-8249

文摘

In multiple sclerosis (MS), using simultaneous magnetic resonance&ndash;positron emission tomography (MR-PET) imaging with <sup>11sup>C-PBR28, we quantified expression of the 18kDa translocator protein (TSPO), a marker of activated microglia/macrophages, in cortex, cortical lesions, deep gray matter (GM), white matter (WM) lesions, and normal-appearing WM (NAWM) to investigate the in vivo pathological and clinical relevance of neuroinflammation.