Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics

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• 作者：Natalie P. Archer ; Virginia Perez-Andreu ; Michael E. Scheurer ; Karen R. Rabin ; Erin C. Peckham-Gregory ; Sharon E. Plon ; Ryan C. Zabriskie ; Pedro A. De Alarcon ; Karen S. Fernandez ; Cesar R. Najera ; Jun J. Yang ; Federico Antillon-Klussmann and Philip J. Lupo
• 刊名：Cancer
• 出版年：2016
• 出版时间：December 1, 2016
• 年：2016
• 卷：122
• 期：23
• 页码：3697-3704
• 全文大小：210K
• ISSN：1097-0142

文摘

Children of Hispanic ancestry have a higher incidence of acute lymphoblastic leukemia (ALL) compared with other ethnic groups, but to the authors' knowledge, the genetic basis for these racial disparities remain incompletely understood. Genome-wide association studies of childhood ALL to date have focused on inherited genetic effects; however, maternal genetic effects (the role of the maternal genotype on phenotype development in the offspring) also may play a role in ALL susceptibility.