Quercetin suppresses lung cancer growth by targeting Aurora B kinase

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• 作者：Zhu Xingyu ; Ma Peijie ; Peng Dan ; Wang Youg ; Wang Daojun ; Chen Xinzheng ; Zhang Xijun and Song Yangrong
• 刊名：Cancer Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：5
• 期：11
• 页码：3156-3165
• 全文大小：551K
• ISSN：2045-7634

文摘

aurora B kinase is highly expressed in several cancer cells and promotes tumorigenesis and progression, and therefore, it is an important target for drug to treat tumors. Quercetin was identified to be an antitumor agent. Herein, we report for the first time that quercetin inhibited aurora B activities by directly binding with aurora B in vitro and in vivo. Ex vivo studies showed that quercetin inhibited aurora B activities in JB6 Cl41 cells and A549 lung cancer cells. Moreover, knockdown of aurora B in A549 cells decreased their sensitivities to quercetin. In vivo study demonstrated that injection of quercetin in A549 tumor-bearing mice effectively suppressed cancer growth. The phosphorylation of histone 3 in tumor tissues was also decreased after quercetin treatment. In short, quercetin can suppress growth of lung cancer cells as an aurora B inhibitor both in vitro and in vivo.