Computational analysis of liquid chromatography-tandem mass spectrometric steroid profiling in NCI H295R cells following angiotensin II, forskolin and abiraterone treatment
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- 作者：Anastasios Mangelisa ; Anastasios.Mangelis@uniklinikum-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Peter Dieterichb ; Mirko Peitzscha ; Susan Richtera ; Ramona Jü ; hlenc ; Angela Hü ; bnerc ; Holger S. Willenbergd ; e ; Andreas Deussenb ; Jacques W.M. Lendersd ; f ; Graeme Eisenhofera ; d
- 关键词：StAR ; steroidogenic acute regulatory protein ; CYP11A1 ; cholesterol side-chain cleavage enzyme ; CYP17 ; 17-alpha-hydroxylase/17 ; 20-lyase ; 3β -HSD ; 3-beta-hydroxysteroid dehydrogenase ; CYP21A1 ; 21 hydroxylase ; CYP11B1 ; 11-beta-hydroxylase ; CYP11B2 ; aldosterone synthase ; RMSE ; root mean square error ; DHEA ; dehydroepiandrosterone
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：155
- 期：part_PA
- 页码：67-75
- 全文大小：1787 K
文摘
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An LC–MS/MS based computational analysis of steroidogenesis is proposed.
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Multiple time point measurements reveal dynamics of induced perturbations.
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The computational analysis successfully describes steroid production.
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Calculated reaction rate constants appropriately reflect effects of agents.
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