4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials

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• 作者：Verotta ; Luisella ; Lovaglio ; Erminio ; Vidari ; Giovanni ; Finzi ; Paola Vita ; Neri ; Maria Grazia ; et. al.
• 关键词：Mesua ferrea ; Guttiferae ; 4-Alkyl and 4-phenyl 5 ; 7-dihydroxycoumarins
• 刊名：Phytochemistry
• 出版年：2004
• 出版时间：November, 2004
• 年：2004
• 卷：65
• 期：21
• 页码：2867-2879
• 全文大小：413 K

文摘

Supercritical CO₂ selectively extracted a series of 4-alkyl and 4-phenyl 5,7-dihydroxycoumarins from Mesua ferrea blossoms. Chemical modifications of the isolated compounds allowed us to confirm the structures elucidated by spectroscopic means and to prepare new derivatives amenable to SAR studies and potential pharmaceutical development. Biological investigations towards the screening on a number of bacteria strains and Plasmodium falciparum, identified compounds 1aaa9 as weak antiprotozoal agents and potent antibacterials on resistant Gram-positive strains.