Combined circulating epigenetic markers to improve mesothelin performance in the diagnosis of malignant mesothelioma
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- 作者：Lory Santarellia ; Sara Staffolania ; Elisabetta Strafellaa ; Linda Nocchia ; Nicola Manzellaa ; Paola Grossia ; Massimo Braccia ; Elettra Pignottib ; Renata Allevab ; Battista Borghib ; Cecilia Pompilic ; Armando Sabbatinic ; Corrado Rubinid ; Lina Zuccatostae ; Elisabetta Bichisecchif ; Matteo Valentinoa ; Keith Horwoodg ; Manola Comarh ; Massimo Bovenzih ; Lan-Feng Dongi ; Jiri Neuzili ; j ; Monica Amatia ; Marco Tomasettia ; m.tomasetti@univpm.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：MM ; malignant mesothelioma ; LC ; lung cancer ; SMRPs ; soluble mesothelin-related proteins ; miR-126 ; microRNA-126 ; Met-TM ; methylated thrombomodulin ; TM ; thrombomodulin ; EGFL7 ; EGF-like-domain ; multiple 7 ; ROC ; Receiver operating characteristics ; AUC ; area under curve ; Cf ; cumulative fibers ; CCL2 ; chemokine (C&ndash ; C motif) ligand 2 ; CEA ; carcinoembryonic antigen
- 刊名：Lung Cancer
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：90
- 期：3
- 页码：457-464
- 全文大小：1287 K
文摘
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MM patients showed high levels of SMRPs and Met-TM and low miR-126.
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SMRPs and miR-126, but not Met-TM are prognostic factors for MM.
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The 3-biomarker model differentiate MM patients from high-risk and healthy subjects.
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Epigenetic biomarkers with SMRPs overcomes the limitations of using SMRPs alone.
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The 3-biomarker combination distinguish MM from lung cancer.
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