The effect of metformin on neuronal activity in the appetite-regulating brain regions of mice fed a high-fat diet during an anorectic period
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- 作者：Hyun-Ju Kim1 ; Bo-Yeong Jin1 ; Mi-Jeong Oh ; Kyung-Ho Shin ; Sang-Hyun Choi ; Dong-Hoon Kim ; LDHKIM@korea.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：VMH ; ventromedial hypothalamic nucleus ; PVN ; paraventricular nucleus ; DMH ; dorsomedial hypothalamic nucleus ; ARC ; hypothalamic arcuate nucleus ; LH ; lateral hypothalamic area ; CeA ; Central amygdala ; BLA ; basolateral amygdala ; MeA ; medial amygdala ; GCL ; granule cell layer of the hippocampal dentate gyrus ; AcbC ; nucleus accumbens core ; AcbSh ; nucleus accumbens shell ; VTA ; ventral tegmental area ; NTS ; nucleus tractus solitarius ; AP ; area postrema
- 刊名：Physiology & Behavior
- 出版年：2016
- 出版时间：1 February 2016
- 年：2016
- 卷：154
- 期：Complete
- 页码：184-190
- 全文大小：891 K
文摘
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We identified brain regions involved in metformin-induced anorexia.
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Metformin caused weight loss and anorexia in obese mice fed a high fat diet.
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Acute metformin activated neurons in the PVN, AP, and CeA.
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Repeated metformin activated neurons independent of weight loss and anorexia.
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Repeated metformin administration activated neurons in the VMH, NTS, GCL, and Acb.
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