Design and structure–activity relationship of heterocyclic analogs of 4-amino-3-benzimidazol-2-ylhydroquinolin-2-ones as inhibitors of receptor tyrosine kinases

详细信息    查看全文

• 作者：Kelly Frazier ; Elisa Jazan ; Christopher M. McBride ; Sabina Pecchi ; Paul A. Renhowe ; Cynthia M. Shafer ; Clarke Taylor ; Dirksen Bussiere ; Molly Min He ; Johanna M. Jansen et al.
• 关键词：Vascular endothelial growth factor (VEGF) ; Basic fibroblast growth factor (bFGF) ; Platelet derived growth factor (PDGF)
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2006
• 出版时间：15 April 2006
• 年：2006
• 卷：16
• 期：8
• 页码：2247-2251
• 全文大小：136 K

文摘

Herein are described a series of novel heterocyclic analogs of the 4-amino-3-benzimidazol-2-ylhydroquinolin-2-one scaffold. These compounds are potent inhibitors of receptor tyrosine kinases and exhibit favorable pharmacokinetic profiles. The synthesis and SAR of these compounds are described.