Ventral tegmental area dopaminergic lesion-induced depressive phenotype in the rat is reversed by deep brain stimulation of the medial forebrain bundle
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- 作者：L.L. Furlanetti1 ; V.A. Coenen ; 1 ; volker.coenen@uniklinik-freiburg.de" class="auth_mail" title="E-mail the corresponding author ; M.D. Dö ; brö ; ssy
- 关键词：Depression ; Deep brain stimulation ; Medial forebrain bundle ; Ventral tegmental area ; Dopamine
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：15 February 2016
- 年：2016
- 卷：299
- 期：Complete
- 页码：132-140
- 全文大小：1955 K
文摘
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Results confirm the feasibility of chronic, continuous, bilateral MFB-DBS.
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Bilateral dopamine lesion of the VTA produce depressive-like phenotype in rats.
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MFB-DBS can reverse depressive-like phenotype.
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MFB-DBS activates distant structures involved in the neurocircuitry of depression.
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MFB-DBS can act via both DA dependent or independent mechanisms.
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