Involvement of caspase-3/PTEN signaling pathway in isoflurane-induced decrease of self-renewal capacity of hippocampal neural precursor cells
详细信息 查看全文
- 作者：Xin Chen ; Wei Wang ; Jianfang Zhang ; Shiyong Li ; Yilin Zhao ; Lei Tan ; Ailin Luo ; alluo@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BrdU ; 5׳-Bromo-2-deoxyuridine ; C-C3 ; cleaved (active) ; DAPI ; 4׳ ; ; 6-diamidino-2-phenylindole ; DG ; dentate gyrus ; GFAP ; glial fibrillary acidic protein ; ISO ; isoflurane ; LDH ; lactate dehydrogenase ; NPC ; neural precursor cells ; P1 ; postnatal day 1 ; PTEN ; phosphatase and tensin homolog deleted on chromosome 10 ; Tuj-1 ; neuron specific β3-tubulin ; TUNEL ; Terminal deoxyribonucleotidyl transferase (TDT)-mediated dUTP-digoxigenin nick end labeling
- 刊名：Brain Research
- 出版年：2015
- 出版时间：2 November 2015
- 年：2015
- 卷：1625
- 期：Complete
- 页码：275-286
- 全文大小：6173 K
文摘
- •
Isoflurane decreases proliferation of hippocampal NPCs from developing brain.
- •
Isoflurane increased neuronal differentiation from hippocampal NPCs.
- •
Caspase-3 plays critical roles in isoflurane-induced NPCs exhaustation.
- •
PTEN acted downstream of caspase-3 in isoflurane-induced NPCs exhaustation.
- •
Inhibition of caspase-3 or PTEN attenuates isoflurane-induced NPCs exhaustation.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |