Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced Parkinsonian mouse model
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- 作者：Sachchida Nand Rai raibiochem@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Satyndra Kumar Yadav satyndra_yadav@yahoo.co.in" class="auth_mail" title="E-mail the corresponding author ; Divakar Singh singhdivakar686@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Surya Pratap Singh ; suryasingh@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; suryasinghbhu16@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Ursolic acid ; Dopaminergic neuron ; Substantia nigra ; Tyrosine hydroxylase ; Homovanilic acid ; 3 ; 4-Dihydroxyphenylacetic acid
- 刊名：Journal of Chemical Neuroanatomy
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：41-49
- 全文大小：740 K
文摘
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MPTP causes oxidative stress and ultimately neurodegeneration.
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Ursolic acid (UA) improved behavioral impairments caused due to MPTP intoxicity.
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UA has ability to reduce oxidative stress found in PD brain.
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UA protected neurodegeneration caused due to MPTP neurotoxicity.
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UA could be a potential source for the PD treatment.
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