Endoplasmic reticulum stress contributes to acetylcholine receptor degradation by promoting endocytosis in skeletal muscle cells
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- 作者：Ailian Dua ; b ; 1 ; lotusdudu@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Shiqian Huangc ; 1 ; Xiaonan Zhaoc ; Yun Zhanga ; Lixun Zhua ; Ji Dinga ; Congfeng Xuc ; d ; cxu@shsmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：BTX ; bungarotoxin ; CME ; clathrin-mediated endocytosis ; ER stress ; endoplasmic reticulum stress ; ERAD ; endoplasmic reticulum-associated degradation ; MβCD ; methyl-beta-cyclodextrin ; MFI ; mean fluorescence intensity ; AChR ; acetylcholine receptor ; ATF6 ; activating transcription factor 6 ; IRE1 ; inositol-requiring kinase 1 ; PERK ; double-stranded RNA-activated protein kinase (PKR)-like endoplasmic reticulum kinase ; RIDD ; regulated IRE-1-dependent decay of mRNA (RIDD) ; XBP1 ; X-box-binding protein 1
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：290
- 期：Complete
- 页码：109-114
- 全文大小：649 K
文摘
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Endoplasmic reticulum (ER) stress promotes acetylcholine receptor (AChR) endocytosis.
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Accelerated endocytosis of acetylcholine receptor provocates its degradation.
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ER stress contributes to AChR degradation through accelerating endocytosis.
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Suppressing ER stress dampens AChR degradation in skeletal muscle cells.
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