Individual and combined effects of deoxynivalenol and α-zearalenol on cell proliferation and steroidogenesis of granulosa cells in cattle
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- 作者：Fabiola Pizzoa ; Francesca Calonia ; francesca.caloni@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Luis F. Schutzb ; Morgan L. Tottyb ; Leon J. Spicerb
- 关键词：GC ; granulosa cells ; LGGC ; large-follicle granulosa cells ; SMGC ; small-follicle granulosa cells ; E2 ; estradiol ; P4 ; progesterone ; DON ; deoxynivalenol ; ZEA ; zearalenone ; α-Zol ; α-zearalenol ; RIA ; radioimmunoassay ; FCS ; fetal calf serum ; DMEM ; Dulbecco's Modified Eagle Medium ; IGF ; insuline-like growth factor ; FSH ; follicle-stimulating hormone
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：40
- 期：3
- 页码：722-728
- 全文大小：880 K
文摘
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Deoxynivalenol and zearalenone are mycotoxins produced by Fusarium species.
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Granulosa cells were used to test the effects of deoxynivalenol and α-zearalenol.
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Deoxynivalenol and α-zearalenol were tested alone and in combination.
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Deoxynivalenol and α-zearalenol had effects on in vitro granulosa cells function.
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Further studies are needed to better understand their effects on bovine species.
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