MicroRNA-128b suppresses tumor growth and promotes apoptosis by targeting A2bR in gastric cancer
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- 作者：Ping Wanga ; Xueyan Guoa ; Wei Zonga ; Bin Songb ; Guisheng Liua ; Shuixiang Hec ; fisrstsxianghe@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gastric cancer ; miR-128b ; A2bR ; Proliferation ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：27 November 2015
- 年：2015
- 卷：467
- 期：4
- 页码：798-804
- 全文大小：1206 K
文摘
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The expression of MiR-128b is significantly down-regulated in GC tissues and cell lines.
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Ectopic expression of miR-128b directly affects cell proliferation, migration and invasion in vitro.
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Overexpression of miR-128b increases apoptosis in GC cells.
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A2bR is a candidate target gene of miR-128b.
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MiR-128b represses cell proliferation, migration and invasion and promotes apoptosis by targeting A2bR in GC.
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