Tbx16 and Msgn1 are required to establish directional cell migration of zebrafish mesodermal progenitors
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- 作者：Alyssa J. Manning ; David Kimelman ; kimelman@uw.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：EMT ; epithelial to mesenchymal transition ; MET ; mesenchymal to epithelial transition ; Tbx16 ; T-box 16/Spadetail ; Msgn1 ; Mesogenin1 ; MO ; tbx16 ; msgn1 morpholino-treated ; A&ndash ; P ; anterior&ndash ; posterior ; MZ ; maturation zone
- 刊名：Developmental Biology
- 出版年：2015
- 出版时间：15 October 2015
- 年：2015
- 卷：406
- 期：2
- 页码：172-185
- 全文大小：2145 K
文摘
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A method to image the EMT in zebrafish tailbuds at high resolution is established.
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Wild-type cells use productive lamellipodia to migrate persistently anteriorly.
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Cells lacking Tbx16 and Msgn1 are motile but cannot leave the tailbud.
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These mutant cells do not migrate directionally or form productive lamellipodia.
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Embryos have a directional migratory cue that is independent of Tbx16 and Msgn1.
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