MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma

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• 作者：Longhao Sun^a ; ^d ; Corrine Ying Xuan Chua^a ; ^c ; Weijun Tian^d ; Zhixiang Zhang^d ; Paul J. Chiao^b ; ^c ; Wei Zhang^a ; ^b ; ^c ; ^d ; ^{wzhang@mdanderson.org" class="auth_mail" title="E-mail the corresponding author}
• 关键词：MicroRNA ; Signaling pathway ; Tumorigenesis ; Pancreatic ductal adenocarcinoma
• 刊名：Journal of Genetics and Genomics
• 出版年：2015
• 出版时间：20 October 2015
• 年：2015
• 卷：42
• 期：10
• 页码：563-577
• 全文大小：1526 K

文摘

Pancreatic ductal adenocarcinoma (PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. MicroRNAs (miRNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how miRNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression.