A case report of aorto-pulmonary window in an infant born to a diabetic mother

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• 作者：Federico Schena ; MD^a ; ^{federico.schena@mangiagalli.it" class="auth_mail" title="E-mail the corresponding author} ; Alessia Cappelleri ; MD^a ; Irene Picciolli ; MD^a ; Alessandra Mayer ; MD^a ; Gaia Francescato ; MD^a ; Maria Albina Galli ; MD^b ; Carmelo Arcidiacono ; MD^c ; Fabio Mosca ; MD^a
• 关键词：Aorto-pulmonary septal defect ; Conotruncal heart malformations ; Pregnancy in diabetics
• 刊名：Journal of Cardiology Cases
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：6
• 页码：173-175
• 全文大小：290 K

文摘

Several studies have described the association between pre-gestational maternal diabetes and cardiac disease in the newborn. Infants of diabetic mothers have an increased incidence of congenital heart disease, reported between 3% and 6% compared to 0.8% of the general population. A particularly high prevalence of conotruncal defects has been recently described among congenital heart diseases. This group of malformations affects ventricular outflows, aorta, and pulmonary artery and shares a common embryogenic origin. They include persistence of the truncus arteriosus, transposition of great arteries, tetralogy of Fallot, interruption of the aortic arch, and double outlet right ventricle. Aorto-pulmonary window, a rare congenital heart disease belonging to conotruncal malformations, has never been previously described in association with maternal diabetes. We describe the case of a male infant born to a mother suffering from a poorly controlled type 1 diabetes during pregnancy. In the early postnatal life the infant showed respiratory distress, tachycardia, and failure to thrive. He was found to be affected by aorto-pulmonary window that required corrective surgical intervention.

<Learning objective: This case report warns us to consider this congenital abnormality as a possible finding in infants born to a diabetic mother. Furthermore, it shows how difficult the echocardiographic diagnosis of aorto-pulmonary windows can be.>