Immunogenic Stimulus for Germline Precursors of Antibodies that Engage the Influenza Hemagglutinin Receptor-Binding Site
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- 作者：Aaron G. Schmidt1 ; Khoi T. Do1 ; Kevin R. McCarthy1 ; Thomas B. Kepler2 ; Hua-Xin Liao3 ; 4 ; M. Anthony Moody3 ; 5 ; 6 ; Barton F. Haynes3 ; 4 ; 6 ; Stephen C. Harrison1 ; 7 ; harrison@crystal.harvard.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2015
- 出版时间：29 December 2015
- 年：2015
- 卷：13
- 期：12
- 页码：2842-2850
- 全文大小：2946 K
文摘
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UCAs of RBS-directed lineages bind viruses circulating during a donor’s infancy
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H1 viruses circulating after 1995 have escaped binding by lineage UCAs
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Vaccination recalled lineages, with further maturation and increased breadth
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Imprinting by H1 influenza early in life may direct later B cell responses
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