Blockage of TGFβ-SMAD2 by demethylation-activated miR-148a is involved in caffeic acid-induced inhibition of cancer stem cell-like properties in vitro and in vivo
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- 作者：Yuan Lia ; 1 ; Fei Jianga ; 1 ; Lijun Chenb ; 1 ; Ye Yangb ; Shuyuan Caob ; Yuting Yeb ; Xingxing Wanga ; Juan Mua ; Zhong Lia ; Lei Lib ; drleili@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CaA ; 3 ; 4-dihydroxycinnamic acid ; CSCs ; cancer stem cells ; DNMT ; DNA methyltransferases ; HCC ; hepatocellular carcinoma ; miR-148a ; microRNA-148a ; qMSP ; quantitative methylation-specific polymerase chain reaction ; SAM ; S-adenosylmethionine ; TGFβ ; transforming growth factor beta ; TNBC ; triple-negative breast cancer
- 刊名：FEBS Open Bio
- 出版年：2015
- 出版时间：2015
- 年：2015
- 卷：5
- 期：Complete
- 页码：466-475
- 全文大小：3083 K
文摘
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Caffeic acid (CaA) attenuates CSCs-like properties in human cancer cells.
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CaA inhibits the activity/expression of SMAD2.
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CaA elevates the expression of miR-148a by inducing DNA demethylation.
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miR-148a targets SMAD2 in CaA-treated cells.
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CaA attenuates CSCs-like properties via miR-148a.
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