Induced Developmental Arrest of Early Hematopoietic Progenitors Leads to the Generation of Leukocyte Stem Cells
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- 作者：Tomokatsu Ikawa1 ; 2 ; tomokatsu.ikawa@riken.jp" class="auth_mail" title="E-mail the corresponding author ; Kyoko Masuda2 ; 3 ; Mirelle J.A.J. Huijskens4 ; Rumi Satoh2 ; Kiyokazu Kakugawa2 ; Yasutoshi Agata5 ; Tomohiro Miyai1 ; 6 ; Wilfred T.V. Germeraad4 ; Yoshimoto Katsura2 ; 7 ; Hiroshi Kawamoto2 ; 3 ; kawamoto@frontier.kyoto-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 刊名：Stem Cell Reports
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：5
- 期：5
- 页码：716-727
- 全文大小：3022 K
文摘
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Overexpression of ID3 endows hematopoietic progenitors with self-renewal activity
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A simple block of cell differentiation is sufficient to induce stem cells
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Induced leukocyte stem (iLS) cells exhibit robust multi-lineage reconstitution
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Equivalent progenitors were produced from human cord blood hematopoietic stem cells
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