Synthesis of 2-C-methylerythritols and 2-C-methylthreitols via enantiodivergent Sharpless dihydroxylation of trisubstituted olefins

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• 作者：Shibaji K. Ghosh ; Mark S. Butler^&dagger ; ; Martin J. Lear ; ^{Martin.Lear@nus.edu.sg}
• 关键词：Mevalonate ; Erythritol ; Threitol ; Tetraols ; Sharpless ; Dudley ; Enantiodivergent ; Antibiotic ; Malaria ; Microbial ; Parasitic
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：30 May, 2012
• 年：2012
• 卷：53
• 期：22
• 页码：2706-2708
• 全文大小：464 K

文摘

The mevalonate-independent pathway (MIP) is an interesting avenue for antimicrobial lead discovery. Here, we present a unified enantioselective synthesis of all four stereoisomers of 2-C-methyltetrol. These are useful building blocks of many bioactive natural products, including 2-C-methylerythritol phosphate (MEP) of the MIP biosynthetic pathway.