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Allele-Specific Reprogramming of Cancer Metabolism by the Long Non-coding RNA CCAT2
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文摘

The lnRNA CCAT2 reprograms energy metabolism in an allele-specific manner

CCAT2 alleles bind the CFIm complex with distinct affinities

CCAT2-CFIm-GLS interaction regulates the alternative splicing of GLS

This regulation axis is present in 61% of analyzed CRC cases

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