Design, synthesis and biological evaluation of monobactams as antibacterial agents against gram-negative bacteria
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- 作者：Hai-Gen Fu1 ; Xin-Xin Hu1 ; Cong-Ran Li ; Ying-Hong Li ; Yan-Xiang Wang ; Jian-Dong Jiang ; Chong-Wen Bi ; Sheng Tang ; Xue-Fu You ; xuefuyou@126.com" class="auth_mail" title="E-mail the corresponding author ; Dan-Qing Song ; songdanqingsdq@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Monobactam ; Siderophore ; Structure&ndash ; activity relationship ; Antibacterial activity ; Click chemistry
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：3 March 2016
- 年：2016
- 卷：110
- 期：Complete
- 页码：151-163
- 全文大小：1303 K
文摘
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Fourteen monobactams were designed and synthesized.
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Click Chemistry was first applied for the synthesis of monolactams.
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Representative compounds exhibited potency against Gram-negative bacteria.
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Lower ClogP might be a powerful strategy in designing antibacterial agents.
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