Exploring the role of chloro and methyl substitutions in 2-phenylthiomethyl-benzoindole derivatives for 5-LOX enzyme inhibition
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- 作者：Antonella Pedutoa ; Verena Krauthb ; Selene Collarilea ; Fiederike Dehmb ; Marika Ambruosia ; Carmela Belardoa ; Francesca Guidaa ; Antonio Massac ; Veronica Espositod ; Sabatino Maionea ; Mario de Rosaa ; Oliver Werzb ; Rosanna Filosaa ; rosanna.filosa@unina2.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-lipoxygenase ; Leukotriene ; Indoles
- 刊名：European Journal of Medicinal Chemistry
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：108
- 期：Complete
- 页码：466-475
- 全文大小：751 K
文摘
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Molecular modification and optimization process of benzoindoles based agents were applied.
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Compounds 6f and 6l exhibited dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibition.
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Compound 6l caused a reduction of oedema of 77.4%.
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