Cardioprotective effect of miRNA-22 on hypoxia/reoxygenation induced cardiomyocyte injury in neonatal rats
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- 作者：Jian Yanga ; 1 ; Lihua Chenb ; 1 ; Jiawang Dinga ; Jing Zhanga ; Zhixing Fanc ; Chaojun Yangc ; Qinqin Yuc ; Jun Yanga ; yangjun@ctgu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MI/R ; myocardial ischemia/reperfusion ; CBP ; CREB binding protein ; AP-1 ; activator protein-1 ; NF-κB ; nuclear factor kappaB ; H/R ; hypoxia/reoxygenation ; DMEM ; Dulbecco's modified eagle's medium ; FBS ; fetal bovine serum ; MOI ; multiplicities of infection ; CK ; creatine kinase ; LDH ; lactate dehydrogenase ; ECL ; enhanced chemiluminescence ; EMSA ; electrophoretic mobility shift assay ; ELISA ; enzyme-linked immunosorbent assay ; ANOVA ; one-way analysis of variance ; SNK ; Student&ndash ; Newman&ndash ; Keuls
- 刊名：Gene
- 出版年：2016
- 出版时间：15 March 2016
- 年：2016
- 卷：579
- 期：1
- 页码：17-22
- 全文大小：805 K
文摘
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miR-22 protects cardiomyocytes from hypoxia/reoxygenation (H/R)-induced apoptosis and inflammation in vitro.
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miR-22 significantly inhibited CBP-related transcriptional factor AP-1 DNA binding activity under H/R.
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miR-22 plays an important cardioprotective role partly via regulating CBP/AP-1 pathway.
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