Early post-transplant neopterin associated with one year survival and bacteremia in liver transplant recipients

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• 作者：Hani Oweira^a ; ^d ; ¹ ; ^{Hani.Oweira@hirslanden.ch" class="auth_mail" title="E-mail the corresponding author} ; Imad Lahdou^b ; ¹ ; ^{imadlahdo@hotmail.com" class="auth_mail" title="E-mail the corresponding author} ; Volker Daniel^b ; ^{volker.daniel@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Stefan Hofer^c ; ^{stefan.hofer@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Markus Mieth^a ; ^{markus.mieth@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Jan Schmidt^a ; ^d ; ^{Jan.Schmidt@hirslanden.ch" class="auth_mail" title="E-mail the corresponding author} ; Peter Schemmer^a ; ^{peter.schemmer@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Gerhard Opelz^b ; ^{gerhard.opelz@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Arianeb Mehrabi^a ; ^{arianeb.mehrabi@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author} ; Mahmoud Sadeghi^a ; ^{mahmoud.sadeghi@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author}
• 关键词：APACHE ; Acute Physiology and Chronic Health Evaluation ; AUC ; area under curve ; BMI ; body mass index ; CMV ; cytomegalovirus ; CVD ; cardiovascular diseases ; CsA ; cyclosporine A ; ELISA ; enzyme linked immunosorbent assay ; HBV ; hepatitis B virus ; HCC ; hepatocellular carcinoma ; HCs ; healthy controls ; HCV ; hepatitis C virus ; ICU ; intensive care unit ; IFN ; Interferon ; INR ; International Normalized Ratio ; Tx ; transplantation ; MELD ; model for end-stage liver disease ; MMF ; mycophenolate ; NPV ; negative predic
• 刊名：Human Immunology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：77
• 期：1
• 页码：115-120
• 全文大小：536 K

文摘

Bacterial infections are the most common complications, and the major cause of mortality after liver transplantation (Tx). Neopterin, a marker of immune activation, is produced in monocyte/macrophages in response to inflammation. The aim of our study was to investigate whether early post-operation serum levels of neopterin were associated with post-transplant bacteremia and mortality in liver transplant recipients. We studied 162 of 262 liver Tx patients between January 2008 and February 2011 of whom pre- and early post-Tx sera samples were available.

Pre- and early post-operative risk factors of infection and mortality were evaluated in 45 bacteremic patients and 117 non-bacteremic patients. During one-year follow-up, 28 of 262 patients died because of graft failure, septicemia and other diseases.

Post-Tx serum neopterin on day 10 (p < 0.001) were significantly higher in bacteriemic patients than in patients without bacteremia. Logistic regression analyses showed that day 10 post-Tx neopterin serum level ⩾40 nmol/l has a predictive value (OR = 6.86: p < 0.001) for bacteremia and mortality (OR = 3.47: p = 0.021).

Our results suggest that early post-Tx neopterin serum levels are very sensitive predictive markers of one-year post-Tx bacteremia and mortality in liver Tx recipients.