An efficient one-pot protocol for the conversion of benzaldehydes into tetrazole analogs

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• 作者：Khalid Mohammed Khan^a ; ^{hassaan2@super.net.pk" class="auth_mail" title="E-mail the corresponding author} ; ^{khalid.khan@iccs.edu" class="auth_mail" title="E-mail the corresponding author} ; Itrat Fatima^a ; Syed Muhammad Saad^a ; Muhammad Taha^b ; ^c ; Wolfgang Voelter^d
• 关键词：One-pot synthesis ; Oximes ; Nitriles ; Tetrazoles
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：3 February 2016
• 年：2016
• 卷：57
• 期：5
• 页码：523-524
• 全文大小：1104 K

文摘

An efficient protocol has been developed for the one-pot synthesis of tetrazole derivatives in moderate to good yields starting from substituted benzaldehydes and proceeding via non-isolated oxime and nitrile intermediates. The structures of the desired products were confirmed by IR, and NMR spectroscopy as well as mass spectrometry. A plausible reaction mechanism is also discussed.