Comparative immunogenicity of hepatitis B vaccine with different dosages and schedules in healthy young adults in China
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- 作者：Zhen-Zi Wanga ; 1 ; Ming-Qiang Lib ; 1 ; Ping Wangb ; Zhen-Xing Yangb ; Lin Weib ; Ying Zengc ; Yan-Ping Lid ; Ling Yana ; Xue-En Liua ; xueenliu@bjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Hui Zhuanga ; zhuangbmu@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anti-HBc ; antibody against hepatitis B core antigen ; Anti-HBs ; antibody against hepatitis B surface antigen ; CI ; confidence interval ; GMC ; geometric mean concentration ; HBcAg ; hepatitis B core antigen ; HBsAg ; hepatitis B surface antigen ; HBV ; hepatitis B virus ; S/CO ; sample signal-to-cutoff ratio ; SD ; standard deviation
- 刊名：Vaccine
- 出版年：2016
- 出版时间：17 February 2016
- 年：2016
- 卷：34
- 期：8
- 页码：1034-1039
- 全文大小：464 K
文摘
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To compare immunogenicity of HBV vaccine between 20 μg (0−1−6 month) and 60 μg (0−1 or 0−2 month) regimens in adults.
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No differences in seroprotection rates among three vaccine groups at month 7/2/3 or 12.
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The similar GMCs were observed in 20 μg (0−1−6 month) and 60 μg (0−2 month) groups at month 7/3.
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A higher GMC level was induced by 3-dose (20 μg) HBV vaccine than by 2-dose (60 μg) at month 12.
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All formulations of HBV vaccine were well tolerated with the incidence of adverse reactions <3%.
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