Evaluation of the use of non-pathogenic porcine circovirus type 1 as a vaccine delivery virus vector to express antigenic epitopes of porcine reproductive and respiratory syndrome virus
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- 作者：Pablo E. Piñ ; eyroa ; b ; Scott P. Kenneya ; Luis G. Gimé ; nez-Lirolab ; Tanja Opriessnigb ; c ; Debin Tiana ; C. Lynn Heffrona ; Xiang-Jin Menga ; xjmeng@vt.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Vaccine delivery vector ; Porcine circovirus type 1 (PCV1) ; Porcine reproductive and respiratory syndrome virus (PRRSV) ; Antigenic epitopes ; Porcine circovirus type 2 (PCV2)
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：100-108
- 全文大小：1468 K
文摘
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Four chimeric PCV1 viruses expressing known antigenic epitopes of PRRSV were constructed and rescued.
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The chimeric viruses were stable and infectious in vitro and three chimeric viruses were infectious in pigs.
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The PCV1-VR2385EPI chimeric viruses elicited neutralizing antibodies against PRRSV VR2385 strain.
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The non-pathogenic PCV1 potentially may serve as a vaccine delivery vector.
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