2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol (SQ0814061), a novel microtubule inhibitor, evokes G2/M cell cycle arrest and apoptosis in human breast cancer cells
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- 作者：Jingwen Xua ; Daiying Zuoa ; Huan Qia ; Qirong Shenb ; Zhaoshi Baia ; Mengting Hana ; Zengqiang Lia ; Weige Zhangb ; zhangweige2000@sina.com" class="auth_mail" title="E-mail the corresponding author ; Yingliang Wua ; yingliang_1016@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Combretastatin A-4 ; G2/M arrest ; Apoptosis ; Breast cancer ; MDM2
- 刊名：Biomedicine & Pharmacotherapy
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：308-321
- 全文大小：5901 K
文摘
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SQ is a newly synthesized analog of combretastatin A-4.
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SQ is a novel microtubule inhibitor.
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SQ exhibits potent anti-breast cancer properties.
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SQ induced G2/M phase arrest and apoptosis in MCF-7 and MDA-MB-231 cells.
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The apoptosis induced by SQ is associated with PI3K-Akt-MDM2 pathway.
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