Tumor necrosis factor alpha suppresses osteogenic differentiation of MSCs by inhibiting semaphorin 3B via Wnt/β-catenin signaling in estrogen-deficiency induced osteoporosis
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- 作者：Chenglin Sanga ; b ; c ; Yongxian Zhangb ; c ; Fangjing Chenb ; c ; Ping Huanga ; Jin Qia ; Pingshan Wangb ; c ; Qi Zhoua ; Hui Kanga ; Xuecheng Caob ; c ; caoxuecheng_sm@126.com" class="auth_mail" title="E-mail the corresponding author ; Lei Guoa ; guolei607@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：TNF-α ; Tumor necrosis factor alpha ; MSCs ; Mesenchymal stem cells ; Sema ; Semaphorin ; OVX ; Ovariectomized ; BMMSCs ; Bone marrow mesenchymal stem cells ; ANCs ; All nucleated cells ; α-MEM ; Alpha minimum essential medium ; FBS ; Fetal bovine serum ; anti-TNF-α ; Neutralizing antibody ; BV/TV ; Bone volume/tissue volume ; Tb.Th ; Trabecular thickness ; Tb.N ; Trabecular number ; BMD ; Bone mineral density ; mMSCs ; Mouse MSCs ; NC ; Negative control ; qRT-PCR ; Quantitative real-time PCR analysis ; OC ; Osteocalcin ; ALP ; A
- 刊名：Bone
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：84
- 期：Complete
- 页码：78-87
- 全文大小：1632 K
文摘
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TNF-α could decrease Sema3B expression during osteogenic differentiation of MSCs process.
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Inhibition of Sema3B expression was required for TNF-α-mediated MSCs proliferation and osteogenic differentiation.
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Wnt/β-catenin signaling was involved in the regulation of Sema3B expression by TNF-α.
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