There is experimental evidence linking bone and energy metabolism in mice, and that osteocalcin (OC) plays an important role.

A unique aspect of this study is that all the three forms (i.e., total, carboxylated and undercarboxylated OC) were assessed.

The three OC forms were evaluated in relation to metabolic and anthropometric parameters in normal and overweight children.

Carboxylated OC levels were lower in young overweight prepubertal children in comparison with normal weight children.

The current study does not support the hypothesis of an association between OC and positive a metabolic profile.