Patient-derived xenograft models of squamous cell carcinoma of the uterine cervix
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- 作者：Einar K. Rofstad ; einar.k.rofstad@rr-research.no" class="auth_mail" title="E-mail the corresponding author ; Trude G. Simonsen ; Ruixia Huang ; Lise Mari K. Andersen ; Kanthi Galappathi ; Christine Ellingsen ; Catherine S. Wegner ; Anette Hauge ; Jon-Vidar Gaustad
- 关键词：Cervical carcinoma ; PDX models ; Metastasis ; Cancer stem cells ; Lymphangiogenesis
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：10 April 2016
- 年：2016
- 卷：373
- 期：2
- 页码：147-155
- 全文大小：4556 K
文摘
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The PDX models mirror the biology and aggressiveness of the donor patients' tumors.
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Metastasis of the PDXs is associated with the presence of intratumoral lymphatics.
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Metastasis of the PDXs is related to high expression of angiogenesis-related genes.
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Metastasis of the PDXs correlates with high expression of stem cell-related genes.
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