Methicillin-susceptible strains responsible for postoperative orthopedic infection are not selected by the use of cefazolin in prophylaxis

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• 作者：Sophie Trouillet-Assant^a ; ^b ; ^{sophie.assant@chu-lyon.fr" class="auth_mail" title="E-mail the corresponding author} ; Florent Valour^a ; ^c ; William Mouton^a ; ^b ; Patrí ; cia Martins-Simõ ; es^a ; ^b ; Sé ; bastien Lustig^a ; ^d ; Fré ; dé ; ric Laurent^a ; ^b ; Tristan Ferry^a ; ^c ; on behalf of the Lyon BJI study group
• 关键词：Staphylococcus aureus ; Prophylaxis ; Cefazolin ; Bone and joint infection ; β-Lactamase
• 刊名：Diagnostic Microbiology & Infectious Disease
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：84
• 期：3
• 页码：266-267
• 全文大小：171 K

文摘

Comparison of methicillin-susceptible Staphylococcus aureus (MSSA) isolates responsible for bone and joint infection (BJI, n = 73) and nasal colonization (n = 57) revealed similar prevalence of β-lactamase (blaZ) type A production, associated with cefazolin hydrolysis, suggesting that blaZ type A–carrying MSSA isolates implicated in postoperative BJI are not selected by cefazolin prophylaxis.