Long term follow up of the EORTC 18952 trial of adjuvant therapy in resected stage IIB-III cutaneous melanoma patients comparing intermediate doses of interferon-alpha-2b (IFN) with observation: Ulceration of primary is key determinant for IFN-sensitivity
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- 作者：Alexander M.M. Eggermonta ; alexander.eggermont@gustaveroussy.fr" class="auth_mail" title="E-mail the corresponding author ; Stefan Suciub ; Piotr Rutkowskic ; Willem H. Kruitd ; Cornelis J. Punte ; Reinhard Dummerf ; Franç ; ois Salè ; sg ; Ulrich Keilholzh ; Gaetan de Schaetzenb ; Alessandro Testorii ; for the EORTC Melanoma Group
- 关键词：Melanoma ; Adjuvant ; Interferon ; Ulceration ; Predictive factors ; Randomised trial
- 刊名：European Journal of Cancer
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：111-121
- 全文大小：2157 K
文摘
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The 25-month interferon (IFN) schedule yielded to better outcome than the observation group.
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Ulceration of the primary is a strong predictive factor for IFN-alpha sensitivity.
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Stage IIB–IIIN1 patients with an ulcerated primary had the highest treatment benefit.
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