The study included a group of 165 pregnant women (59 women with preeclampsia and 109 healthy pregnant women). DNA was extracted from peripheral blood. Determination of the polymorphism of −344C > T CYP11B2 gene and 2238T > C ANP gene was performed by PCR-RFLP method.
The results showed that the frequencies of the TC and CC genotypes of 2238T > C polymorphism in ANP gene were significantly higher in patients with PE compared to control group. For −344C > T polymorphism of CYP11B2 gene, the frequency of TT genotype was significantly higher in patients with hypertension than in controls (32.2% vs. 23.58%).
Our findings showed that gene polymorphism of CYP11B2 (−344C > T) and ANP (2238T > C) may be associated with developing PE during pregnancy.
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