A single oral dose of flavan-3-ols enhances energy expenditure by sympathetic nerve stimulation in mice
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- 作者：Naoya Kamio ; Takuma Suzuki ; Yuto Watanabe ; Yoshitomo Suhara ; Naomi Osakabe ; nao-osa@sic.shibaura-it.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：FL ; flavan 3-ols ; EE ; energy expenditure ; UCP ; uncoupling protein ; PGC-1α ; receptor gamma coactivator-1 alpha ; AMPK ; AMP-activated protein kinase ; AR ; adrenalin receptor ; SNS ; sympathetic nerve system ; RER ; respiratory exchange ratio ; VCO2 ; carbon dioxide production ; VO2 ; oxygen consumption ; CA ; catecholamine
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：256-263
- 全文大小：1630 K
文摘
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Flavan 3-ols (FL) increase energy expenditure (EE), pAMPK, PGC-1α and UCPs.
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Rising EE, muscle pAMPK and UCP-3 by FL was reduced by β2 adrenaline blocker (ARB).
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Increase of EE, brown adipose PGC-1α and UCP-1 by FL was reduced by β3-ARB.
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Rising UCPs and PGC-1α by FL was reduced by β3 and β2-ARB, but not EE and pAMPK.
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